Everyone knows that I have a weak spot for Swiss skincare. In fact, Meder Beauty is one of my favorite brands. But today I am going to introduce you to another Swiss brand that’s new to me this year, Evenswiss. I’ll talk about specifically their Eventone Serum and Booster No7. I have been using this serum duo for several months. They’re almost empty. I feel I gave them enough time to work and am ready to talk about them.
All Evenswiss products contains their patented ingredient Dermatopoietin Peptide Complex. Dermatopoietin is their trademark name for interleukin-1 alpha. This natural cytokine, which is a major regulator of the immune response, plays also an important role for skin and hair renewal. It acts as biochemical messenger between skin cells and activates the maintenance process of skin, restores the skin barrier function and regulates the hair cycle.
Dermatopoietin is always used in combination with Hexadeltine. These two compounds are referred to as Dermatopoietin Peptide Complex. Hexadeltine is a Leu-enkephalin analogue (delta-opioid) with the structure Tyr – D-Ala – Gly – Phe – Leu – Asp. It prevents excessive release of IL1a from keratinocytes. Delta-opioids have in addition anti-inflammatory properties; they potentiate growth factors and stimulate capillary blood flow.
As we age the production of IL1a declines, which leads to disturbed skin and hair renewal and many of the typical signs of aging skin. EVENSWISS with Dermatopoietin helps to provide the skin with the optimum level of IL1a and thereby restores the skin renewal process. It reactivates the production of collagen and elastin, which gives the skin its strength and elasticity. It furthermore triggers the release of several growth and differentiation factors which are essential for healthy and youthful skin and hair.
Our skin is an impenetrable barrier from the outside world. It’s extremely hard to penetrate without causing irritation, damage, and weakened the epidermal barrier. Peptide is big molecule and Dermatopoietin is no exception and you might think it won’t penetrate skin so what’s the point? It’s true. It’s a big challenge that formulator face. We need a vehicle delivery of actives to the deep skin layer for it to work without causing any irritation. Evenswiss employ cell signaling approach. DP sends a signal from a skin’s surface to the skin depth and begins production of collagen and elastin in the dermis.
Skin cells communicate with each other and when one cell releases a signal, other cells respond to it. Interleukin-1 alpha (IL1-α) is a specific signal produced by cells of epidermal barrier. This signal is unique: it may be delivered over long distance, from skin’s surface across all epidermal layers to specific target cells (fibroblasts) in the dermis. Once dermal fibroblasts receive such signal, they begin production of all valuable skin components: collagen, elastin, and hyaluronic acid. The interleukin-1 alpha signalling across epidermal barrier provides a basis for unique “signalling cosmetics” based on delivery of a signal, instead of a substance, to the depth of the skin. There is no longer need in physical delivery of cosmetic ingredients to the skin depth. Signalling cosmetics delivers a signal, but not a cosmetic ingredient per se, to the skin depth to begin a skin renovation program.
From “Imiquimod-Induced Interleukin-1α Stimulation Improves Barrier Homeostasis in Aged Murine Epidermis”. Department of Dermatology, University of California at San Francisco, and Veterans Affairs Medical Center, San Francisco, California, USA.
- “Administration of intracutaneous IL-1α improves barrier function in aged animals. To determine directly whether in vivo administration of IL-1α improves barrier function, IL-1α 50 ng in 50 μL PBS versus the vehicle alone was injected intracutaneously into the flanks of aged and young BALB/c mice (25 mo old (n=6) versus 6–12 wk old (n=6)). The dose of IL-1α (50 ng) was chosen because it is comparable to those employed in prior studies in rodents (Granstein et al, 1986). Because of possible systemic effects of the intracutaneous IL-1α, separate mice were used for IL-1α-treated and vehicle-treated groups. The barrier was perturbed by tape stripping immediately following the injection, and barrier recovery rates were compared.. Barrier recovery kinetics accelerated significantly in both IL-1α-treated young and aged mice versus vehicle-treated controls, but the extent of improvement was greater in aged animals, remaining significant to at least 24 h post-IL-1α administration. These results show that exogenous IL-1α accelerates epidermal permeability barrier recovery in both aged and young mice, with more significant improvement in aged skin.”
- “IL-1α treatment normalizes lamellar bilayer structure in aged epidermis. Prior studies have shown that the barrier abnormality in aged mice is associated with reduced numbers of lamellar bodies, decreased secreted lamellar body contents, and patchy reductions in extracellular lamellar bilayers (Ghadially et al, 1995). As the most marked acceleration in barrier recovery is apparent 3–6 h after IL-1α administration, we compared the lamellar body secretory system and SC morphology at these time points. As seen in Figure 4, IL-1α treatment increased the density of lamellar bodies in the cytosol of cells in the outer stratum granulosum, as well as the amounts of secreted organelle contents at the stratum granulosum–SC interface. Moreover, whereas vehicle-treated, aged epidermis displayed little or no return of extracellular lamellar bilayers, IL-1α-treated samples displayed bilayer quantities comparable to young murine skin at comparable time points after barrier disruption (Figure 5; see alsoGhadially et al, 1995). Finally, the number of lamellar bodies was increased in IL-1α-treated samples (Figure 5; see alsoGhadially et al, 1995). Together, these results demonstrate that the IL-1α-stimulated acceleration of barrier recovery is paralleled by a normalization of the lamellar body secretory system and its resultant bilayers in aged epidermis.”
- “IL-1α increases lipid synthesis in cultured human keratinocytes. Because of the limited availability of aged mice, we performed further mechanistic studies in cultured keratinocytes. To determine whether the IL-1α-stimulated increase in lamellar body secretion reflects increased lipid synthesis, we next assessed whether exogenous IL-1α directly stimulates keratinocyte lipid production in cultured human keratinocytes. IL-1α (10 ng per mL) or vehicle alone was added to second passage, cultured human keratinocytes (n=6), grown under serum- and growth-factor-free conditions for the prior 24 h. After 24 h total lipid synthesis increased by approximately 25% in IL-1α-treated cultured human keratinocytes (p=0.002). Synthesis of both nonsaponifiable and saponifiable lipids was increased significantly (41%, p=0.00, and 16%, p=0.02, respectively) Figure 6. These results show that exogenous IL-1α directly stimulates lipid synthesis in cultured keratinocytes, correlating with both increased lamellar body production and barrier recovery in cytokine-treated, aged tissues. Barrier recovery of the epidermis is associated with an increase in lipid synthesis of barrier associated lipids. IL-1α administration resulted in increased lipid synthesis in cultured human keratinocytes. The greatest increase was in the more profoundly defective lipid (in human epidermis), cholesterol.”
It’s a novel approach and I’m all about gentle! Results without irritations. Some might have some reservation about taking this approach. We just have to know when is enough and when to take advantage of the advanced technology.
Evenswiss products do contain fragrance but they do have certificates to show that the concentration of the fragrance in their products is in compliance with the Standards of the INTERNATIONAL FRAGRANCE ASSOCIATION IFRA. Their products also are paraben free.
Sorry for the lengthy information above! Now getting to the products that I tried….
Ingredients list:
Eventone Serum
Aqua, Biosaccharide gum-1, Glycerin, Pentylene Glycol, Phenyl Trimethicone, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Dicaprylyl Ether, Butylene Glycol, Methyl Methacrylate Crosspolymer, Cyclopentasiloxane, Cyclohexa- siloxane, Hamamelis Virginiana Extract, Hydrogenated Polyisobutene, Potassium Cetyl Phosphate, Trisodium Ascorbyl Palmitate Phosphate, Imidazolidinyl Urea, Phenoxyethanol, Carbomer, Arctostaphylos Uva Ursi Leaf Extract, Magnesium Ascorbyl Phosphate, Sodium Benzoate, Rumex Occidentalis Extract, Alcohol, Parfum, Ascorbic Acid, Sodium Hydroxide, Citric Acid, Sodium Metabisulfite, Sodium Hyaluronate, Nonapeptide-1, Narcissus Tazetta Bulb Extract, Dextran, Citrus Lemon Peel Extract, Mentha Piperita Extract, Potassium Sorbate, Chlorophenesin, Hexapeptide-18, Sh-Polypeptide-17.
Trade name: Dermatopoietin for human interleukin-1 alpha (IL-1a). INCI name: sh-Polypeptide-17.
Trade name: Hexadeltine for hexapeptide Tyr- D-Ala-Gly-Phe-Leu-Asp. INCI name Hexapeptide-18.
Nonapeptide-1: also called Melanostatine™ 5. Nonapeptide-1 can prevent melanin synthesis and unwanted pigmentation by preventing activation of the tyrosinase. It promote radiance and also has antimicrobial activities.
Arctostaphylos Uva Ursi Leaf Extract: or Bearberry. One of my favorite extract for brightening!
BOOSTER No7
Aqua (Water), Pentylene Glycol, Arbutin, Titanium Dioxide, Hexylresorcinol, Cocoyl Proline, Sodium Hyaluronate, Lepidum Sativum Sprout Extract, Lecithin, Glycerin, Tocopheryl Acetate, Glutathione, Ascorbyl Palmitate, Decyl Glucoside, Xanthan Gum, Linolenic Acid, Linoleic Acid, Alcohol, Ethylhexylglycerin, Peg-100 Stearate, Phenoxyethanol, Acrylates/Vinyl Isodecanoate Crosspolymer
Who is it for?
Anyone who want to brighten their complexion
Texture/smell:
Eventone serum has a jelly thick serum texture. It spread really well and left skin with a silky feel. It take some massage to sink in but non tacky.
Booster No7 is a thin milky liquid
Both products just like the rest of the line have a very light refreshing, flowery scent. It dissipate quickly and it didn’t bother me.
How do you use it?
Instructions from the brand: “Mix 1 part of Booster No7 and 1 part of Master Booster with 10 parts of Base Formula Face, Body or Massage or alternatively with 10 parts of the appropriate EVENSWISS® retail line product”.
The way I used it: I mixed three pumps of the Eventone Serum with one drop of Booster 7. Applied to clean face after toning step. Sometimes, I mixed these two with my other serums and apply all at once. Massage until sink in. I used twice daily in the AM and PM.
My Results:
Don’t expect overnight miracle with these. As with all products that helps skin repair itself. It takes time. I didn’t see any improvement of my skin during the first few weeks. With consistent use after more than a month I started noticing my skin getting brighter and more radiance. It didn’t lighten my sunspots but give my skin an overall glow. So it does “improve radiance” as claimed. I didn’t expect it to lighten my sunspots. They’re tough to fix. With all products that I used, my sunspots are lighten somewhat but didn’t go away. Products I’m using are to prevent it from getting darker and preventing the new one from appearing. Once I found a safe gentle routine that works I’ll make sure to let you know!
Overall, I enjoyed these duo and please with the results! If you want to brighten your overall complexion, to get the glow from within- I highly recommend these two! If you don’t have many sunspots just dull complexion you will definitely see the change faster or more apparently.
These did capture my interest and it makes me curious about other products in the line especially the Regenerating Plasma, Anti-age spot Booster and Booster number 3! As you can see I’m a sucker for anything brightening!
Price & where to buy?
Eventone Serum retailed for $160/50ml This is bigger bottle when compare to typical serum bottle of 30ml.
Booster 7 retailed for $78/20ml You only need one drop so it last a while!
You can order these at Evenswiss.us
*Products were provided without the obligation for review. Opinions are always honest and my own!